Opportunity Information: Apply for PAR 21 092
The NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity from the National Institute on Drug Abuse (NIDA) designed to push promising medication ideas further down the real-world drug development path. It is aimed at researchers who can take discoveries from basic science and/or clinical research and translate them into actual therapeutic candidates for substance use disorders (SUDs). The program is specifically focused on medications intended to treat SUDs related to tobacco, cannabis, cocaine, methamphetamine, heroin, or prescription opioid use, with an emphasis on moving molecules closer to eventual Food and Drug Administration (FDA) approval.
This opportunity uses a cooperative agreement mechanism, meaning awardees should expect substantial NIH/NIDA involvement compared with a standard research grant. The funding mechanism is structured as UG3/UH3, which generally reflects a phased approach: an initial stage supporting milestone-driven planning and early development activities (UG3), followed by a second stage intended to support more advanced development once specific milestones are met (UH3). The notice indicates that clinical trials are optional, which signals that projects may focus on preclinical development, translational studies, early clinical work, or a combination, so long as the proposed work credibly advances a medication candidate along the development continuum.
A central expectation is that applicants can demonstrate a credible capability to develop molecules with therapeutic potential and to advance those candidates through recognized steps of drug development. In practical terms, this typically means applicants should be able to show a compelling scientific rationale and target or mechanism, evidence supporting a lead compound or series, and a well-structured plan for activities such as lead optimization, pharmacology, safety-related studies, formulation, and other translational elements that make a candidate more viable for regulatory progression. The overall goal is not simply to generate academic knowledge, but to create a realistic path toward a medication that could ultimately meet regulatory requirements and be positioned for FDA review.
The program falls under the U.S. Department of Health and Human Services (HHS), NIH, and is listed under CFDA number 93.279. It is categorized as a discretionary grant opportunity and sits within the education and health activity area, reflecting NIH's broader mission to improve health through research while also supporting the training and development of translational research capabilities.
Eligibility is broad and includes many types of domestic organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations other than small businesses; small businesses; and other entities as described in the opportunity's additional eligibility information. This wide eligibility scope is consistent with the translational nature of the program, which often benefits from participation by academic groups, medical centers, nonprofits, and industry or industry-like development teams.
In terms of scale and competitiveness, the opportunity lists an award ceiling of $1,000,000 and anticipates making about two awards. That combination of a relatively high cap and a small expected number of awards signals a selective program intended for highly compelling, well-justified projects with strong teams and a clear development strategy. The opportunity was created on December 21, 2020, and lists an original closing date of July 25, 2023, under Funding Opportunity Number PAR-21-092.
Overall, the NIDA Translational Avant-Garde Award is best understood as a targeted translational pipeline accelerator for SUD medication development: it supports investigators who can bridge discovery and product-oriented development, emphasizes concrete advancement of therapeutic molecules, and aims to reduce the gap between promising research findings and viable, FDA-approvable medications for high-impact substance use disorders.Apply for PAR 21 092
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on Dec 21, 2020.
- Applicants must submit their applications by Jul 25, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Health
Next opportunity: 2021 Alumni Engagement Innovation Fund
Previous opportunity: Comprehensive Evaluation of Recommended Actions to Limit Fishery Escapement from Reservoirs
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 21 092
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 21 092) also looked into and applied for these:
| Funding Opportunity |
|---|
| HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) Apply for RFA DA 21 029 Funding Number: RFA DA 21 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $575,000 |
| Limited Competition to Convert the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Study Cohort to a Research Resource (R24 - Clinical Trial Not Allowed) Apply for RFA MH 21 170 Funding Number: RFA MH 21 170 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Proteogenomic Data Analysis Centers (PGDACs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 024 Funding Number: RFA CA 21 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Proteogenomic Translational Research Centers (PTRCs) for Clinical Proteomic Tumor Analysis Consortium (U01 Clinical Trial Not Allowed) Apply for RFA CA 21 025 Funding Number: RFA CA 21 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 023 Funding Number: RFA CA 21 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 21 037 Funding Number: RFA CA 21 037 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Coordinating Center for Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) in Cancer Survivors Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 032 Funding Number: RFA CA 21 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $875,000 |
| Network of the National Library of Medicine All of Us Program Center (U24) (Clinical Trial Optional) Apply for RFA LM 21 002 Funding Number: RFA LM 21 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,200,000 |
| Cancer Target Discovery and Development (CTD2) (U01 Clinical Trial Not Allowed) Apply for PAR 21 274 Funding Number: PAR 21 274 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Indian Health Service National Indian Health Outreach and Education Apply for HHS 2023 IHS NIHOE 0001 Funding Number: HHS 2023 IHS NIHOE 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Education, Health Funding Amount: $851,311 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 032 Funding Number: RFA CA 22 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Apply for RFA CA 22 046 Funding Number: RFA CA 22 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Translational Research Centers (U01 Clinical Trial Optional) Apply for RFA CA 22 031 Funding Number: RFA CA 22 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| American Indians into Medicine Apply for HHS 2024 IHS INMED 0001 Funding Number: HHS 2024 IHS INMED 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $700,000 |
| American Indians into Nursing Apply for HHS 2024 IHS NU 0001 Funding Number: HHS 2024 IHS NU 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $400,000 |
| American Indians into Psychology Apply for HHS 2024 IHS INPSY 0001 Funding Number: HHS 2024 IHS INPSY 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $267,500 |
| Limited Competition: Childhood Cancer Survivor Study (U24) Apply for RFA CA 15 502 Funding Number: RFA CA 15 502 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,700,000 |
| Collaborative Aging (in Place) Research Using Technology (CART) (U2C) Apply for RFA AG 16 021 Funding Number: RFA AG 16 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Proteogenomic Translational Research for Clinical Proteomic Tumor Analysis Consortium (U01) Apply for RFA CA 15 022 Funding Number: RFA CA 15 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $910,000 |
| Mechanisms, Models, Measurement, and Management in Pain Research (R21) Apply for PA 16 187 Funding Number: PA 16 187 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 21 092", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.