Opportunity Information: Apply for RFA CA 17 006
The Cancer Immunologic Data Commons (CIDC) (U24) funding opportunity (RFA-CA-17-006) is a National Institutes of Health (NIH) cooperative agreement designed to stand up a single, centralized bioinformatics and data commons resource to support correlative science tied to cancer immunotherapy clinical trials. The core idea is to create an informatics backbone for a broader network that will generate, harmonize, store, and analyze immunologic and related biomarker data coming out of trials, so that results can be compared across studies and used more effectively to understand treatment response, resistance, and patient outcomes. In practical terms, the CIDC is meant to function as a shared platform and service hub that enables consistent data handling and cross-trial analytics for immuno-oncology.
This FOA specifically supports one CIDC award that will operate as part of a larger “Network for correlative studies in clinical trials involving cancer immunotherapy.” That network is structured around two components: (1) the single CIDC funded under this announcement and (2) up to three Cancer Immune Monitoring and Analysis Centers (CIMACs) funded under the companion announcement RFA-CA-17-005. The CIMACs are the laboratory and immune-monitoring engines that generate standardized assay data from clinical trial specimens, while the CIDC is the central bioinformatics, data management, and integration entity that makes those data usable at scale. Because the award mechanism is a cooperative agreement (U24), recipients should expect substantial scientific and programmatic involvement from NIH compared to a standard research grant, including coordination expectations, shared governance, and network-wide deliverables.
From an applicant and eligibility standpoint, the opportunity is broad within the United States and its territories, reflecting NIH’s intent to attract strong academic, nonprofit, governmental, and private-sector capabilities in data commons infrastructure and biomedical informatics. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations that are not federally recognized tribal governments. It also allows public housing authorities/Indian housing authorities, nonprofits (both 501(c)(3) and non-501(c)(3) organizations, excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses. The FOA also explicitly calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, the FOA places clear limits on foreign participation. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. In other words, the CIDC award is intended to be fully U.S.-based in terms of applicant organization and project components, which matters for teams that might otherwise consider hosting infrastructure, staffing, or substantial analytic work outside the U.S.
Key administrative details help frame the scale and timing of the opportunity. The agency is NIH, the opportunity category is discretionary, and it falls under education and health activity categories, with CFDA numbers 93.394 and 93.395. The original posting was created on 2016-12-16, with an original closing date of 2017-03-17. The listed award ceiling is $900,000, indicating the maximum expected annual or total direct cost level as presented in the summary data (applicants typically confirm budget structure and allowable costs in the full FOA text). The summary notes “ExpectedAwards:” but does not provide a number; however, the narrative clarifies that the network will include a single CIDC award under this FOA, so the intent is to fund one main CIDC.
Overall, this grant opportunity is aimed at building a centralized, network-facing immuno-oncology data commons that can reliably support multi-site clinical trial correlative science. It emphasizes shared infrastructure, standardization, and coordinated operations across the CIMAC-CIDC network, with NIH actively involved in oversight and collaboration because of the cooperative agreement structure. The result NIH is looking for is a durable, high-quality bioinformatics and data integration capability that accelerates learning from cancer immunotherapy trials by making immune monitoring and associated clinical and molecular data consistently managed, analyzable, and comparable across studies.Apply for RFA CA 17 006
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Cancer Immunologic Data Commons (CIDC) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2016-12-16.
- Applicants must submit their applications by 2017-03-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Cancer Immunologic Data Commons (CIDC) (U24) funding opportunity?
The CIDC (U24) funding opportunity (RFA-CA-17-006) is a National Institutes of Health (NIH) cooperative agreement to establish a single, centralized bioinformatics and data commons resource that supports correlative science connected to cancer immunotherapy clinical trials.
What is the main goal of the CIDC award?
The goal is to create an informatics backbone that can generate, harmonize, store, and analyze immunologic and related biomarker data from cancer immunotherapy clinical trials so results can be compared across studies and used to better understand treatment response, resistance, and patient outcomes.
How is the CIDC intended to be used in practice?
In practical terms, the CIDC is meant to function as a shared platform and service hub that enables consistent data handling and cross-trial analytics for immuno-oncology, supporting analysis at scale across multiple clinical trials.
Is this opportunity funding more than one CIDC?
No. This FOA supports one CIDC award that will operate as part of a broader network for correlative studies in clinical trials involving cancer immunotherapy.
What larger program or network does the CIDC belong to?
The CIDC operates as part of a larger "Network for correlative studies in clinical trials involving cancer immunotherapy."
What are the two main components of the network described in the opportunity?
The network is structured around (1) a single CIDC funded under this announcement (RFA-CA-17-006) and (2) up to three Cancer Immune Monitoring and Analysis Centers (CIMACs) funded under the companion announcement RFA-CA-17-005.
What is a CIMAC and how does it relate to the CIDC?
The CIMACs are described as the laboratory and immune-monitoring engines that generate standardized assay data from clinical trial specimens. The CIDC is the central bioinformatics, data management, and integration entity that makes those data usable at scale.
What does it mean that this is a cooperative agreement (U24)?
Because the award mechanism is a cooperative agreement (U24), recipients should expect substantial scientific and programmatic involvement from NIH compared to a standard research grant. This includes coordination expectations, shared governance, and network-wide deliverables.
Which agency is offering this funding opportunity?
The agency is the National Institutes of Health (NIH).
What is the FOA number for this CIDC opportunity?
The FOA number is RFA-CA-17-006.
What is the companion announcement mentioned, and why does it matter?
The companion announcement is RFA-CA-17-005, which funds up to three CIMACs. It matters because the CIDC is designed to work closely with the CIMACs as part of the same network, with CIMACs producing standardized assay data and the CIDC managing and integrating the resulting data at scale.
What kinds of data is the CIDC expected to handle?
Based on the description, the CIDC is expected to support immunologic and related biomarker data coming out of cancer immunotherapy clinical trials, with a focus on harmonization, storage, and analysis for cross-trial comparison.
What types of studies does this data commons support?
It supports correlative science tied to cancer immunotherapy clinical trials, with an emphasis on enabling consistent data handling and cross-trial analytics.
Why is cross-trial comparison emphasized in this opportunity?
The opportunity emphasizes cross-trial comparison so that results can be compared across studies and used more effectively to understand treatment response, resistance, and patient outcomes in cancer immunotherapy.
What is the opportunity category and activity focus?
The opportunity category is discretionary. The activity categories listed are education and health.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.394 and 93.395.
Who is eligible to apply for this funding opportunity?
Eligible applicants include a broad set of U.S.-based organizations and government entities, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations that are not federally recognized tribal governments.
Are nonprofit organizations eligible to apply?
Yes. The opportunity allows nonprofits, including both 501(c)(3) and non-501(c)(3) organizations (excluding higher education institutions in those nonprofit categories as stated in the summary).
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also listed as eligible.
Are public housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are listed as eligible.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included among eligible applicant types.
Are faith-based or community-based organizations eligible to apply?
Yes. Faith-based or community-based organizations are explicitly called out as eligible applicant types in the summary information provided.
Are Historically Black Colleges and Universities (HBCUs) and other minority-serving institutions eligible?
Yes. The summary explicitly lists multiple categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISISs, among others.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are listed among the additional eligible applicant types.
Can foreign (non-U.S.) organizations apply for this award?
No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply.
Can a U.S. organization include a non-U.S. (non-domestic) component as part of its application?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed under this FOA?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not allowed under this opportunity.
What is the implication of foreign components not being allowed?
Based on the summary, the CIDC award is intended to be fully U.S.-based in terms of the applicant organization and project components. This affects teams that might otherwise consider hosting infrastructure, staffing, or substantial analytic work outside the U.S.
When was this opportunity originally posted, and what was the original closing date?
The original posting was created on 2016-12-16, and the original closing date was 2017-03-17.
What is the listed award ceiling for this opportunity?
The listed award ceiling is $900,000, presented as the maximum expected annual or total direct cost level in the summary data.
How many awards are expected to be made under this FOA?
The summary notes "ExpectedAwards:" without providing a number. However, the narrative indicates the intent is to fund a single CIDC award under this FOA.
What outcomes is NIH seeking through this CIDC award?
NIH is looking for a durable, high-quality bioinformatics and data integration capability that accelerates learning from cancer immunotherapy trials by making immune monitoring and associated clinical and molecular data consistently managed, analyzable, and comparable across studies.
What are the key responsibilities implied for the CIDC within the network?
The CIDC is described as the central bioinformatics, data management, and integration entity responsible for making standardized assay and related trial data usable at scale, enabling harmonization and cross-trial analytics across the network.
How does NIH involvement differ here compared to a standard grant?
The summary indicates NIH will have substantial scientific and programmatic involvement due to the cooperative agreement structure, including expectations for coordination, shared governance, and network-wide deliverables.
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